Gemma C. Sharp

The paper investigates whether common genetic variants contribute to neurodevelopmental risks in children with cleft lip/palate, finding no strong genetic correlation with psychiatric traits but noting independent clinical relevance of polygenic risk scores.

This study conducts GWAS on orofacial cleft subtypes, identifying 27 genome-wide significant regions, including novel loci, and highlights genetic heterogeneity and homogeneity across subtypes.

This study examines DNA methylation at birth and its association with childhood cognitive skills, finding weak single CpG site associations and one region near DUSP22 linked to non-verbal cognition.

The paper identifies genetic variants influencing DNA methylation in blood and shows their associations with complex traits and diseases, but finds limited direct causality.

This study identifies DNA methylation sites at birth associated with ADHD symptoms later in childhood, but finds no such associations at school age.

This study investigates whether genetic liability to non-syndromic cleft lip/palate influences educational attainment and intelligence, finding little evidence of shared genetic causation.

This study identifies 24 genetic loci associated with facial shape variation in humans through GWAS and confirms 13 of them in a multi-ethnic cohort.

The paper identifies three loci where genetic liability to non-syndromic cleft lip/palate may be mediated by DNA methylation variation in blood and tissue.

The paper investigates genetic overlap between non-syndromic cleft lip/palate and facial morphology using polygenic risk scores and Mendelian randomization, finding a causal relationship with philtrum width.