This study identifies shared genetic variants and gene expression mechanisms between ADHD and migraine using genome-wide association data and multiple genetic analyses.

medRxiv · Aug 21, 2026 · PreprintGenetic & Genomic Medicine

Exploring the causal effects of genetic liability to ADHD and Autism on Alzheimer's disease

Panagiota Pagoni, Christina Dardani, Beate Leppert, Roxanna Korologou‐Linden, George Davey Smith, Laura D Howe, Emma Louise Anderson, Evie Stergiakouli

This study investigates causal links between genetic liability to ADHD, ASD, and Alzheimer's disease using Mendelian randomization, finding limited evidence of association.

Translational Psychiatry · Oct 1, 2022Peer-reviewedGenetics

Is genetic liability to ADHD and ASD causally linked to educational attainment?

Christina Dardani, Lucy Riglin, Beate Leppert, Eleanor C. M. Sanderson, Dheeraj Rai, Laura D Howe, George Davey Smith, Kate M. Tilling, Anita Thapar, Neil M Davies, Emma Louise Anderson, Evie Stergiakouli

This paper uses Mendelian randomization to investigate causal links between genetic liability to ADHD/ASD and educational attainment, finding distinct causal effects for ADHD and ASD.

International Journal of Epidemiology · May 9, 2021Peer-reviewedGenetics

Cleft lip/palate and educational attainment: cause, consequence, or correlation? A Mendelian randomization study

Christina Dardani, Laurence J Howe, Nandita Mukhopadhyay, Evie Stergiakouli, Yvonne E. Wren, Kerry Humphries, Amy Davies, Karen M. Ho, Seth Michael Weinberg, Mary L. Marazita, Elisabeth Mangold, Kerstin U. Ludwig, Caroline Laura Relton, George Davey Smith, Sarah Jane Lewis, , Gemma C. Sharp

This study investigates whether genetic liability to non-syndromic cleft lip/palate influences educational attainment and intelligence, finding little evidence of shared genetic causation.

International Journal of Epidemiology · Mar 6, 2020Peer-reviewedGenetics

Disentangling causal relationships between inflammatory markers and depression: a bidirectional Mendelian randomization analysis

Christina Dardani, James Yarmolinsky, Jamie W. Robinson, Jie Zheng, George Davey Smith, Sarah Jane Lewis, Lindsey Isla Sinclair

This study uses bidirectional Mendelian randomization to investigate causal relationships between inflammatory markers and depression, finding a causal effect of IL-6 on major depressive disorder.

bioRxiv · Nov 25, 2019 · PreprintGenomics