Olivier Messina

The paper shows that chromatin folding is organized by recurrent motifs that are reweighted across cell types and states, revealing a structured framework for chromatin variability.

pyHiM provides a modular, open-source software package for analyzing spatial genomics data from multiplexed DNA-FISH imaging, enabling chromatin trace reconstruction and data validation.

The paper investigates Drosophila insulators' role in 3D chromatin organization, finding that non-border preferential interactions occur before TADs and transcription.

The paper uses Hi-M to study cis-regulatory loops in Drosophila development, showing they form before TADs and gene activation, and are independent of cell fate.