Marie Schaeffer

The paper shows that chromatin folding is organized by recurrent motifs that are reweighted across cell types and states, revealing a structured framework for chromatin variability.

The paper uses multiplexed chromatin imaging to show that Drosophila Polycomb genes predominantly form pairwise long-range interactions rather than clustering during development.

pyHiM provides a modular, open-source software package for analyzing spatial genomics data from multiplexed DNA-FISH imaging, enabling chromatin trace reconstruction and data validation.