Caroline H. Brennan

rbfox1 LoF mutants show disrupted bdnf/trkb2 and crhb/nr3c2 expression and increased cortisol levels during development coupled with signs of allostatic overload in adulthood

This study shows that rbfox1 loss of function in zebrafish disrupts stress-related gene expression and increases cortisol levels during development, leading to behavioral and physiological signs of allostatic overload in adulthood.

Chaperone AIP Couples mTORC1 Activation and Catabolic Metabolism During Neonatal Development

The paper identifies AIP as a regulator that links mTORC1 activation with catabolic metabolism during neonatal development, ensuring metabolic adaptation and survival.

Ordered developmental emergence of number-selective neurons in days-old zebrafish

The paper shows number-selective neurons in zebrafish develop in a sequential order, with neurons for higher numbers appearing later and a decoder based on these neurons can predict visual numerosity.

Biallelic Loss of Molecular Chaperone Molecule AIP Results in a Novel Severe Multisystem Disease Defined by Defective Proteostasis

This study shows that biallelic AIP loss causes a severe pediatric disease with proteostasis defects, observed in human and zebrafish models.

Disrupting fzd9b in zebrafish recapitulates stress- and anxiety-like behaviours associated with Williams syndrome

The paper generates zebrafish mutants with fzd9b disruptions to study anxiety and social behaviors linked to Williams syndrome, finding altered stress responses and compensatory gene upregulation.

Pleiotropic contribution of rbfox1 to psychiatric and neurodevelopmental phenotypes in a zebrafish model

This study investigates the behavioral effects of rbfox1 deficiency in zebrafish, finding multiple behavioral changes that resemble those in Rbfox1-deficient mice and psychiatric patients.

Neurons in the dorso-central division of zebrafish pallium respond to change in visual numerosity

The paper investigates the neural basis of non-symbolic number cognition in zebrafish by examining activation patterns in the pallium during changes in visual numerosity.

Behavioral effects of developmental exposure to JWH-018 in wild type and disrupted in schizophrenia 1 (disc1) mutant zebrafish

This study examines the behavioral effects of developmental JWH-018 exposure in zebrafish and finds no moderation by disc1 mutations in anxiety-like behaviors.

The effects of polygenic risk for psychiatric disorders and smoking behaviour on psychotic experiences in UK Biobank

The paper examines how polygenic risk for psychiatric disorders and smoking behavior influence psychotic experiences in UK Biobank participants, finding independent and synergistic effects.

Identification of Slit3 as a locus affecting nicotine preference in zebrafish and human smoking behaviour

The paper identifies Slit3 as a genetic locus influencing nicotine preference in zebrafish and smoking behavior in humans through mutagenesis screens and SNP analysis.

A fully automated computer based Skinner box for testing learning and memory in zebrafish

This paper introduces a fully automated Skinner box for testing learning and memory in zebrafish, enabling standardized behavioral assays for cognitive function studies.