Rebeca San Martin

This study shows that HGPS disrupts adipogenic lineage maturation through chromatin reorganization defects, despite normal lineage commitment rates.

This study identifies 3D genome compartment changes associated with epithelial-mesenchymal transition and organotropism in breast cancer metastasis.

The paper examines how nuclear lamina association and genome compartmentalization influence gene regulation across different cell types and treatments.

This study identifies transcriptional deficits in HGPS fibroblasts related to mesenchymal differentiation and endochondral ossification, with age-dependent gene expression changes.

This study examines how DNA damage and repair affect 3D genome organization using Hi-C in different cell types, finding cell-type-specific changes and TAD boundary strengthening in repair-proficient cells.