Arco Bast

The paper shows thalamocortical axons target specific dendritic domains in pyramidal tract neurons to enable calcium-dependent spiking and modulate cortical output through sensory input.

This study characterizes the morphological, electrophysiological, and neuromodulatory properties of FOXP2-expressing corticothalamic pyramidal cells in rat neocortical layers 6a and 6b, showing their distinct responses to acetylcholine and dopamine.

The paper develops interpretable models to reveal how synaptic inputs drive action potential output in layer 5 pyramidal tract neurons during sensory stimulation.

The paper shows that cortical pyramidal neurons optimize ion channel distributions for energy-efficient dendritic computations, selecting configurations with low potassium channel density in distal dendrites.

The paper identifies border stratum cells in the neocortex that receive and relay thalamocortical inputs, showing they can drive sensory responses before layer 4.