Christiaan P. J. de Kock

Uncovering the Basis of Human ConnectomeComplexity: The Role of Neuronal Morphology

The paper investigates how human neuronal morphology influences synaptic connectivity complexity and shows that human neuron shapes lead to more complex connectomes compared to rodents.

A Detailed Model for Understanding the Human Neocortex

This study builds a detailed computational model of the human neocortex and compares it to a rat model, revealing differences in cell density, branching complexity, and synaptic connectivity.

Thalamus drives active dendritic computations in cortex

The paper shows thalamocortical axons target specific dendritic domains in pyramidal tract neurons to enable calcium-dependent spiking and modulate cortical output through sensory input.

Human neurons undergo protracted functional maturation into adulthood

This study shows human cortical neurons mature slowly into adulthood, unlike mice, and develops a model to simulate this process across species.

What makes human cortical pyramidal neurons functionally complex

The paper introduces the Functional Complexity Index (FCI) to quantify neuronal functional complexity and finds human cortical pyramidal neurons are more complex than rat neurons due to morpho-electrical differences.

Interpretable modelling of input-output computations in cortex

The paper develops interpretable models to reveal how synaptic inputs drive action potential output in layer 5 pyramidal tract neurons during sensory stimulation.

Morpho-electric and transcriptomic divergence of the layer 1 interneuron repertoire in human versus mouse neocortex

The paper identifies transcriptomic and morpho-electric diversity in human neocortical layer 1 interneurons, revealing greater subclass distinction compared to mouse.

Human voltage-gated Na+ and K+ channel properties underlie sustained fast AP signaling

The paper shows that biophysical properties of Na+ and K+ channels in human pyramidal neurons enable fast and reliable input-output signaling.

Structural and functional specializations of human fast spiking neurons support fast cortical signaling

The paper identifies structural and functional adaptations in human fast spiking neurons that enable fast inhibition despite increased cortical distances.

Signature morpho-electric properties of diverse GABAergic interneurons in the human neocortex

The paper uses viral labeling and Patch-seq to define morpho-electric properties of GABAergic interneurons in human neocortex, revealing functional insights and reclassifying some SST neurons into PVALB subclass.

Morpho-electric and computational properties of three types of human hippocampal CA1 pyramidal neurons

The paper maps morpho-electric and computational properties of human hippocampal CA1 pyramidal neurons and identifies three distinct cell types with unique biophysical features.

Of mice and men: Dendritic architecture differentiates human from mice neuronal networks

The paper compares dendritic architecture in human and mice neuronal networks, finding that human pyramidal cells have greater dendritic complexity, contributing to increased network complexity despite lower neuron density.

Task complexity temporally extends the causal requirement for visual cortex in perception

The paper shows that task complexity extends the time window in which V1 is necessary for perceptual decisions, overlapping with report-related activity and affecting behavioral performance.

The Impact of Neuron Morphology on Cortical Network Architecture

The paper shows that neuron morphology influences cortical network architecture by shaping recurrent or feedforward connectivity patterns based on dendritic and axonal properties.

Neuronal morphology and physiology, functional brain networks and memory in temporal lobe epilepsy

The paper links functional network integration in the default mode network to cellular properties in TLE patients, showing correlations between network centrality and memory performance.

Expansion of cortical layers 2 and 3 in human left temporal cortex associates with verbal intelligence

The paper shows that expanded layers 2 and 3 in the left temporal cortex correlate with higher verbal intelligence scores and specific neuronal features.

Thalamus drives two complementary input strata of the neocortex in parallel

The paper identifies border stratum cells in the neocortex that receive and relay thalamocortical inputs, showing they can drive sensory responses before layer 4.

Prefrontal cortical ChAT-VIP interneurons provide local excitation by cholinergic synaptic transmission and control attention

The paper identifies ChAT-VIP interneurons in the medial prefrontal cortex that use cholinergic transmission to excite neurons and influence attention.

Large and fast human pyramidal neurons associate with intelligence

The paper links human intelligence to neuronal complexity and action potential speed in pyramidal neurons using brain tissue and imaging data.

Human cortical pyramidal neurons: From spines to spikes via models

The paper presents detailed biophysical models of human cortical pyramidal neurons, revealing enhanced computational capabilities through large synaptic conductances and multi-site nonlinear signaling.