Dirk Feldmeyer

Serotonin Engages Divergent 5-HT Receptor Pathways for Cell Type-Resolved Modulation of Prefrontal Layer 5 Microcircuits

This study investigates how serotonin modulates different cell types in the prefrontal cortex through distinct receptor pathways, revealing cell-type-specific effects on excitability and synaptic transmission.

Morphoelectric properties of inhibitory neurons shift gradually and regardless of cell type along the depth of the cerebral cortex

The paper quantifies morphoelectric properties of inhibitory neurons across cortical depth in rat and mouse brains, finding depth-dependent shifts that apply to all cell types and molecular subtypes.

Transport-Related Effects on Intrinsic and Synaptic Properties of Human Cortical Neurons: A Comparative Study

This study compares intrinsic and synaptic properties of human cortical neurons recorded on-site and off-site after a 30-40 minute transport, finding altered membrane potential, synaptic efficacy, and dendritic spine density.

Linking Altered Neuronal and Synaptic Properties to Nicotinic Receptor Alpha5 Subunit Gene Dysfunction: A Translational Investigation in Rat mPFC and Human Cortical Layer 6

This study investigates how genetic dysfunction in the nicotinic receptor alpha5 subunit affects neuronal and synaptic properties in rat and human cortical layer 6 neurons.

FOXP2-immunoreactive, corticothalamic pyramidal cells in neocortical layers 6a and 6b are tightly regulated by neuromodulatory systems

This study characterizes the morphological, electrophysiological, and neuromodulatory properties of FOXP2-expressing corticothalamic pyramidal cells in rat neocortical layers 6a and 6b, showing their distinct responses to acetylcholine and dopamine.

A Layered Microcircuit Model of Somatosensory Cortex with Three Interneuron Types and Cell-Type-Specific Short-Term Plasticity

The paper develops a multi-layer model of somatosensory cortex with three interneuron types and cell-type-specific short-term plasticity, reproducing experimental observations on network dynamics and inhibitory effects.

Adenosinergic modulation of layer 6 microcircuitry in the medial prefrontal cortex is specific to presynaptic cell type

The paper investigates adenosinergic modulation in layer 6 of the medial prefrontal cortex in rats, revealing differential A1AR expression and synaptic sensitivity between two excitatory neuron subtypes.

Modulation of Giant Depolarizing Potentials (GDPs) in Human Large Basket Cells by Norepinephrine and Acetylcholine

This study identifies and characterizes giant depolarizing potentials (GDPs) in human neocortical neurons, showing their modulation by norepinephrine and acetylcholine.

Cell-type specific neuromodulation of excitatory and inhibitory neurons via muscarinic acetylcholine receptors in layer 4 of rat barrel cortex

This study shows that low concentrations of acetylcholine differentially modulate excitatory and inhibitory neurons in rat barrel cortex layer 4 through specific muscarinic and nicotinic receptor activation.

Functional and structural properties of highly responsive somatosensory neurons in mouse barrel cortex

The paper identifies highly responsive somatosensory neurons in mouse barrel cortex and shows their distinct functional and structural properties compared to less active neurons.

Layer 6A pyramidal cells subtypes form synaptic microcircuits with distinct functional and structural properties

The paper identifies three subtypes of layer 6A pyramidal cells in rat barrel cortex and characterizes their distinct synaptic properties and connectivity patterns.

Layer-specific inhibitory microcircuits of layer 6 interneurons in rat prefrontal cortex

The paper identifies four distinct clusters of layer 6 interneurons in rat medial prefrontal cortex based on axonal projections and firing patterns, suggesting they have different functional roles.

Cell Type-Specific Modulation of Layer 6A Excitatory Microcircuits by Acetylcholine in Rat Barrel Cortex

The paper shows that acetylcholine modulates excitability and synaptic release in different layer 6A pyramidal cell types in rat barrel cortex through distinct receptor mechanisms.