Charity L. Washam

This study shows that GBPs balance iNOS and ARG-1 in myeloid cells to control Leishmania major infection, with GBPChr3 knockout mice showing increased parasite load and disease severity.

This study shows that host inflammatory responses, not the parasite, drive HIF-α signaling in macrophages during Leishmania major infection, leading to HIF-α-dependent suppression of protein translation in a pro-inflammatory environment.

The paper presents a proteogenomic approach to identify resistance-specific alterations in melanoma PDX models treated with MAPK inhibitors using custom curated databases.