This study identifies HDAC1's role in promoting multidrug resistance in pancreatic cancer through chromatin remodeling and develops a prognostic gene signature.

BMC Cancer · Nov 23, 2023Peer-reviewedGenomics

Contributions of rare and common variation to early-onset and atypical dementia risk

Carter Wright, Jared W. Taylor, J. Nicholas Cochran, James M.J. Lawlor, Belle A. Moyers, Michelle D. Amaral, Zachary T Bonnstetter, Princess Carter, Veronika Solomon, R Myers, Marissa Natelson Love, David Geldmacher, Sara J. Cooper, Erik D. Roberson

The paper analyzes genomic data from early-onset and atypical dementia patients to show that both rare and common genetic variations contribute to dementia risk.

Molecular Case Studies · Jun 1, 2023Peer-reviewedGenetic & Genomic Medicine

Pooled CRISPR screening in pancreatic cancer cells implicates co-repressor complexes as a cause of multiple drug resistance via regulation of epithelial-to-mesenchymal transition

Ryne C. Ramaker, Andrew A. Hardigan, Emily R. Gordon, Carter Wright, R Myers, Sara J. Cooper

The paper uses CRISPR screens to identify co-repressor complexes as mediators of drug resistance in pancreatic cancer by regulating epithelial-to-mesenchymal transition.

bioRxiv · Oct 27, 2020 · PreprintGenomics