This study identifies genetic variants associated with Alzheimer's disease and frontotemporal dementia in admixed Latin American populations using whole-genome sequencing and ancestry analysis.

npj Dementia · Jan 21, 2026Peer-reviewedGenetic & Genomic Medicine

KOLF2.1J iTF-Microglia: A standardized platform to studymicroglial transcriptional regulatory networks in CNS disease

Iván Rodríguez-Nunez, Samuel C. Bartley, Jared W. Taylor, S. Quinn Johnston, Brianne B. Rogers, Sarah Kristen Meadows, Kimberly M. Newberry, J. Nicholas Cochran, R Myers

The paper introduces a standardized iPSC-derived microglia model to study transcriptional regulatory networks in CNS diseases and identifies disease-associated genetic variants.

bioRxiv · May 30, 2025 · PreprintGenomics

Contributions of rare and common variation to early-onset and atypical dementia risk

Carter Wright, Jared W. Taylor, J. Nicholas Cochran, James M.J. Lawlor, Belle A. Moyers, Michelle D. Amaral, Zachary T Bonnstetter, Princess Carter, Veronika Solomon, R Myers, Marissa Natelson Love, David Geldmacher, Sara J. Cooper, Erik D. Roberson

The paper analyzes genomic data from early-onset and atypical dementia patients to show that both rare and common genetic variations contribute to dementia risk.

Molecular Case Studies · Jun 1, 2023Peer-reviewedGenetic & Genomic Medicine

MAPT expression is mediated by long-range interactions with cis-regulatory elements

Brianne B. Rogers, Ashlyn G. Anderson, Shelby N. Lauzon, M. Natalie Davis, Rebecca M. Hauser, Sydney C. Roberts, Iván Rodríguez-Nunez, Katie Trausch‐Lowther, Erin A. Barinaga, Jared W. Taylor, Mark Mackiewicz, Brian S. Roberts, Sara J. Cooper, Lindsay F. Rizzardi, R Myers, J. Nicholas Cochran

The paper identifies cis-regulatory elements (cCREs) controlling MAPT expression and links genetic variation in these elements to Alzheimer's disease risk.

bioRxiv · Mar 7, 2023 · PreprintGenomics