This study identifies HDAC1's role in promoting multidrug resistance in pancreatic cancer through chromatin remodeling and develops a prognostic gene signature.

BMC Cancer · Nov 23, 2023Peer-reviewedGenomics

Structural basis for the tryptophan sensitivity of TnaC-mediated ribosome stalling

Anne‐Xander van der Stel, Emily R. Gordon, Arnab Sengupta, Allyson K. Martínez, Dorota Klepacki, Thomas N. Perry, Alba Herrero del Valle, Nora Vázquez‐Laslop, Matthew S. Sachs, Luis Rogelio Cruz-Vera, C. Axel Innis

The paper investigates how the TnaC-ribosome complex recognizes and responds to L-Trp, revealing a mechanism involving cleavage rates and ligand binding.

Nature Communications · Sep 9, 2021Peer-reviewedMolecular Biology

Pooled CRISPR screening in pancreatic cancer cells implicates co-repressor complexes as a cause of multiple drug resistance via regulation of epithelial-to-mesenchymal transition

Ryne C. Ramaker, Andrew A. Hardigan, Emily R. Gordon, Carter Wright, R Myers, Sara J. Cooper

The paper uses CRISPR screens to identify co-repressor complexes as mediators of drug resistance in pancreatic cancer by regulating epithelial-to-mesenchymal transition.

bioRxiv · Oct 27, 2020 · PreprintGenomics

R2DGC: Threshold-free peak alignment and identification for 2D gas chromatography mass spectrometry in R

Ryne C. Ramaker, Emily R. Gordon, Sara J. Cooper

R2DGC aligns and identifies peaks in 2D gas chromatography-mass spectrometry data without thresholds, using R.

Bioinformatics · Dec 20, 2017Peer-reviewedBioinformatics