Cell BiologybioRxivPreprint
Spatial organization of supercoil dynamics during DNA replication
Yoshiharu Kusano, Soya Shinkai, Ryu‐Suke Nozawa…·Toru Hirota
This study shows that SMC5/6-mediated confinement of negative supercoils enables Top2A to resolve them during DNA replication, ensuring genome stability, and identifies over-accumulation of supercoils in cancer cells.