Soya Shinkai

This study shows that SMC5/6-mediated confinement of negative supercoils enables Top2A to resolve them during DNA replication, ensuring genome stability, and identifies over-accumulation of supercoils in cancer cells.

The paper examines enhancer-promoter interactions in mouse embryonic stem cells, finding that transcriptional activity increases genomic viscosity, stabilizing these interactions.

PHi-C2 converts Hi-C data into dynamic 3D genome models using polymer modeling and provides an optimized algorithm and Colab workflow for analysis.

PHi-C simulates dynamic 3D genome features from Hi-C data, aligning with live-cell imaging observations and providing physical insights.

The paper uses single-nucleosome imaging and a polymer model to show that nucleosome movement within chromatin domains is subdiffusive and reflects domain structure and compactness.