Uncovering the isoform-resolution kinetic landscape of nonsense-mediated mRNA decay with EZbakR
Justin W. Mabin, Isaac W. Vock, Martin Machyna, Nazmul Haque, Poonam Thakran, Alexandra Zhang, Ganesha Rai, Isabelle Nathalie-Marie Leibler, James Inglese, Matthew D. Simon, J. Robert Hogg
The paper introduces a method to infer isoform-level kinetics of nonsense-mediated mRNA decay using short-read NR-seq data, revealing variability in NMD efficiency and decay rates of transcripts with and without PTCs.
Genome biology · Jul 15, 2026Peer-reviewedMolecular Biology