Isaac W. Vock

The paper introduces a method to infer isoform-level kinetics of nonsense-mediated mRNA decay using short-read NR-seq data, revealing variability in NMD efficiency and decay rates of transcripts with and without PTCs.

This study identifies TRMT61B as an m1A methyltransferase active on cytosolic mRNAs and shows context-dependent effects of m1A on translation and ribosome recruitment.

RNAdecayCafe provides a uniformly processed atlas of RNA half-life estimates across 11 human cell lines, revealing RNA stability's role in gene expression.

The paper introduces EZbakR and fastq2EZbakR tools to enhance NR-seq data analysis by supporting multi-label modeling, improved variance accounting, and flexible statistical comparisons.

The paper develops CoSTseq to study nascent RNA base pairing in yeast, revealing rapid folding dynamics and helicase roles in ribosome biogenesis.

The paper develops bakR, a Bayesian method to compare RNA kinetic parameters across conditions using NR-seq data, validated on simulated and real datasets.