James Inglese

The paper introduces a method to infer isoform-level kinetics of nonsense-mediated mRNA decay using short-read NR-seq data, revealing variability in NMD efficiency and decay rates of transcripts with and without PTCs.

The paper reports chemoselective halogenation of Premarineosin A, yielding analogs with retained antiplasmodial activity against both sensitive and resistant Plasmodium falciparum strains.

This study uses metabolic engineering and late-stage functionalization to expand the chemical diversity of the antimalarial compound premarineosin A, identifying potent analogs.

This study shows that celastrol and AZD1981 increase Δ133p53 levels and reduce senescence and IL-6 secretion in HGPS-derived fibroblasts, independent of progerin levels.

This paper introduces DAEMS, a system combining ion mobility and acoustic ejection mass spectrometry for high throughput screening of isomerization-mediated enzyme drug targets.

The paper introduces qHTSWaterfall, a 3D visualization tool for qHTS data, enabling the plotting of concentration-response curves with EC50 and Hill slope parameters.