Author

Marleen Van den Broeck

University of AntwerpORCID 0000-0001-7357-0694Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Genetics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Research Focus:benchmarking· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Assay:scRNA-seq· 1 Research Focus:software / tool· 1

Frequent Co-Authors

Rosa RademakersiD· 3 shared Wouter De CosteriD· 3 shared Dennis W. DicksoniD· 2 shared Aivi T. NguyeniD· 1 shared Alexey G. Murzin· 1 shared Andrew KingiD· 1 shared Benjamin FalconiD· 1 shared Bernardino Francesco GhettiiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersGenetics

Rosa RademakersORCID

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3 papers

Recent·Most cited

Targeted single-nucleus sequencing of 39,800 neurons reveals extensive low-frequency somatic variants

Vanshika Bidhan, Sarah Wynants, Toon Swings, Cristina T Vicente, Fahri Küçükali, Marleen Van den Broeck, Jeroen van Rooij, Merel O. Mol, Laura Donker Kaat, Safa Al-Sarraj, István Bódi, Andrew King, Claire Troakes, Christos Proukakis, Jolien M. Schaeverbeke, , Rosa Rademakers

The paper analyzes somatic mutations in neurons from FTLD-TDP type C patients and controls, finding extensive low-frequency variants in TARDBP and other genes.

bioRxiv · Sep 23, 2026 · PreprintGenetics

Distinct TAF15 amyloid filament folds define multiple subtypes of FTLD-TAF15

Stephan Tetter, Nikhil R. Varghese, Alexey G. Murzin, Wouter De Coster, Marleen Van den Broeck, Sigrun Roeber, Jeffrey T. Joseph, Kathy L. Newell, Rudolf J. Castellani, Sumit Das, Lee-Cyn Ang, Matthis Synofzik, Jochen Wolfgang Herms, Rosa Rademakers, Bernardino Francesco Ghetti, , Benjamin Falcon

This study identifies distinct TAF15 amyloid filament structures in different FTLD-FET subtypes, leading to the renaming of the disease group as FTLD-TAF15.

bioRxiv · Jan 12, 2026 · PreprintMolecular Biology

Methylmap: visualization of modified nucleotides for large cohort sizes

Elise Coopman, Marleen Van den Broeck, Tim De Pooter, Geert Joris, Dennis W. Dickson, Mojca Stražišar, Rosa Rademakers, Wouter De Coster

Methylmap visualizes modified nucleotide frequencies across positions for large sample cohorts using standardized BAM/CRAM files.

BMC Bioinformatics · Mar 26, 2025Peer-reviewedBioinformatics