Sigrun Roeber

Molecular Disease Stages of Oligodendrocytic and Neuronal Tau Burden in Progressive Supranuclear Palsy

This paper identifies molecular progression trajectories in PSP by integrating snATACseq and snRNAseq data with tau pathology, revealing cell-type-specific transcriptional changes and glial reactivity.

Ischemic injury triggers a protective microglial phenotype in models of Aβ pathology

The paper investigates how ischemic injury affects microglial response to Aβ pathology, finding a protective microglial phenotype that promotes benign Aβ plaque formation.

A reproducible human brain tissue model to study physiological and disease-associated microglia phenotypes

This paper develops a 3D cortical brain tissue model with mature microglia that recapitulates Alzheimer's disease hallmarks and enables study of microglia phenotypes.

Distinct TAF15 amyloid filament folds define multiple subtypes of FTLD-TAF15

This study identifies distinct TAF15 amyloid filament structures in different FTLD-FET subtypes, leading to the renaming of the disease group as FTLD-TAF15.

Deciphering Distinct Genetic Risk Factors for FTLD-TDP Pathological Subtypes via Whole-Genome Sequencing

This study identifies genetic risk factors for FTLD-TDP subtypes using whole-genome sequencing and meta-analysis across multiple cohorts.

Alpha-Synuclein co-pathology in Alzheimer's Disease drives tau accumulation

This study shows that alpha-Synuclein co-pathology in Alzheimer's Disease increases tau levels, linking AD and Parkinson's Disease pathogenesis.

Genetic, transcriptomic, histological, and biochemical analysis of progressive supranuclear palsy implicates glial activation and novel risk genes

This study identifies six genetic loci associated with progressive supranuclear palsy, including a novel locus, and links them to oligodendrocytic dysfunction and C4A expression.

Whole-Genome Sequencing Analysis Reveals New Susceptibility Loci and Structural Variants Associated with Progressive Supranuclear Palsy

This study uses whole-genome sequencing to identify new genetic loci and structural variants associated with progressive supranuclear palsy, including novel signals in APOE and H1/H2 haplotype region variants.

Neuronal and oligodendroglial but not astroglial tau translates to in vivo tau-PET signals in primary tauopathies

This study shows that neuronal and oligodendroglial tau, but not astroglial tau, contribute to tau-PET signals in 4-repeat tauopathies.