Author

Nikhil R. Varghese

MRC Laboratory of Molecular Biology

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:host-pathogen & immune response· 1 Assay:structural biology· 1

Frequent Co-Authors

Stephan TetteriD· 2 shared Alexey G. Murzin· 1 shared Ann E. McDermottiD· 1 shared Benjamin FalconiD· 1 shared Bernardino Francesco GhettiiD· 1 shared Brayden Williams· 1 shared Chengming HeiD· 1 shared Chi L.L. PhamiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBiophysics

Stephan TetterORCID

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2 papers

Recent·Most cited

BiophysicsProceedings of the National Academy of SciencesPeer-reviewedApr 27, 2026

Structural Studies of an Anti-necroptosis Viral:Human Functional Hetero-amyloid M45:RIPK3 using SSNMR

Chengming He, Nikhil R. Varghese, Eric G. Keeler…·Ann E. McDermott

This paper reports the high-resolution structure of a viral:host hetero-amyloid complex between M45 and RIPK3, revealing its mechanism of inhibiting necroptosis.

3 citations

humanstructural biology

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Molecular BiologybioRxivPreprintJan 12, 2026

Distinct TAF15 amyloid filament folds define multiple subtypes of FTLD-TAF15

Stephan Tetter, Nikhil R. Varghese, Alexey G. Murzin…·Benjamin Falcon

This study identifies distinct TAF15 amyloid filament structures in different FTLD-FET subtypes, leading to the renaming of the disease group as FTLD-TAF15.

1 citation

humanexperimental assay

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