Joseph W. Wragg

This paper develops an embryonic zebrafish xenograft model to assess the efficacy of multi-receptor tyrosine kinase inhibitors in rhabdomyosarcoma, identifying VEGF-A as a potential biomarker for Regorafenib response.

The paper creates a central repository for zebrafish developmental genomics data, identifies new cis-regulatory elements, and compares regulatory elements between zebrafish and mouse.

The paper identifies dual-initiation promoters in zebrafish that use both canonical and non-canonical initiation motifs, showing differential regulation during development and conservation across species.

The paper shows that during zebrafish embryonic development, core promoter architecture changes correlate with cell cycle dynamics and lineage-specific gene expression.

The paper identifies a nuclear transcription compartment that enables early gene expression before genome activation in metazoan embryos.