Rui M. Monteiro

This study shows Dll4 and Jag1a sequentially and cooperatively regulate hematopoietic stem cell fate by modulating MAPK signaling and shear stress during endothelial-to-hematopoietic transition.

This study shows that septins are required for haematopoiesis in zebrafish, as septin-deficient larvae have increased HSPCs and myeloid bias, with implications for blood disorders.

This paper develops an embryonic zebrafish xenograft model to assess the efficacy of multi-receptor tyrosine kinase inhibitors in rhabdomyosarcoma, identifying VEGF-A as a potential biomarker for Regorafenib response.

This study shows that deleting a conserved zebrafish Gata2 enhancer impairs haemogenic endothelium programming and adult haematopoiesis, leading to bone marrow failure and immune defects.

The paper describes an optimized pipeline for genotyping zebrafish embryos after in situ hybridization and digitally quantifying gene expression, improving accuracy and reducing bias.