Cancer BiologybioRxivPreprint
Targetable Treatment Resistance in Thyroid Cancer with Clonal Hematopoiesis
Vera Tiedje, Pablo Sánchez Vela, Julie L. Yang…·Ross L. Levine
This study identifies TET2-mutant clonal hematopoiesis in thyroid cancer microenvironments and shows that TGFβ signaling from these macrophages mediates resistance to BRAF/MEK inhibition, with TGFβ inhibition restoring sensitivity.