Author

Gordon Chandler Werthmann

The University of Texas Southwestern Medical CenterORCID 0000-0001-7370-3928Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

Joachim HerziD· 2 shared Bret M. EversiD· 1 shared Charles L. WhiteiD· 1 shared Connie Hau Yan WongiD· 1 shared Jade Connor· 1 shared Murat S. DurakoglugiliD· 1 shared Robert E Hammer· 1 shared Takaomi C. SaidoiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersNeuroscience

Joachim HerzORCID

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2 papers

Recent·Most cited

NeurosciencebioRxivPreprintMar 10, 2026

Distinct lysosomal dysfunction patterns of GRN deficiency in the CNS implicate progranulin in cell type-specific protein sorting

Gordon Chandler Werthmann, Joachim Herz

The paper identifies cell type-specific lysosomal dysfunction in GRN deficiency using LysoIP and mass spectrometry, revealing progranulin's role in lysosomal protein sorting.

1 citation

mouseproteomics

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NeuroscienceeLifePeer-reviewedOct 7, 2021

NHE6-Depletion Corrects ApoE4-Mediated Synaptic Impairments and Reduces Amyloid Plaque Load

Theresa Pohlkamp, Xunde Xian, Connie Hau Yan Wong…·Joachim Herz

This study shows that NHE6 inhibition corrects ApoE4-mediated synaptic impairments and reduces amyloid plaque load, suggesting a potential therapeutic strategy for Alzheimer's disease.

45 citations

humanexperimental assay

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