Joachim Herz

This study shows that chronic PDGF signaling increases VSMC apoptosis in atherosclerotic plaques by promoting PI3K-dependent c-Myc expression and reducing Bcl-2, leading to plaque instability.

This study shows how non-coding variants in CD33 affect Alzheimer's risk by altering CD33M dimerization and interactions with clusterin and Aβ, impacting microglial function.

The paper identifies cell type-specific lysosomal dysfunction in GRN deficiency using LysoIP and mass spectrometry, revealing progranulin's role in lysosomal protein sorting.

This study shows that NHE6 inhibition corrects ApoE4-mediated synaptic impairments and reduces amyloid plaque load, suggesting a potential therapeutic strategy for Alzheimer's disease.