Savio Ho-Chit Chow

EpiATLAS provides a comprehensive collection of human reference epigenomes to advance epigenomic research and understanding of cellular function and disease.

The paper identifies a widespread transcript leakage issue in spatial transcriptomics and introduces DeLeakage, a Bayesian method that improves data cleaning and cell-type annotation.

The paper models transcript isoform expression levels using epigenomic data from 324 human samples, showing that a universal model outperforms tissue-specific models.

The paper investigates how three-dimensional chromatin domain structures influence gene regulation and finds that domain surfaces are enriched for regulatory elements and disease variants.

This study identifies epigenetic changes in HCC that affect cis-regulatory elements and retrotransposons, linking them to gene dysregulation and poor prognosis.

The paper introduces psirc, a method to identify and quantify full-length circRNA isoforms from RNA sequencing data, showing its effectiveness on cancer and normal tissue samples.