Hans Degens

Nanoscale spatial confinement of proton flux by cardiolipin drives high-speed lateral proton transport in mitochondria

This paper models proton transport in mitochondria, showing cardiolipin creates a nanoscale barrier that confines protons, enabling efficient lateral transport for ATP synthesis.

Skeletal muscle hypertrophy rewires glucose metabolism: an experimental investigation and systematic review

This study investigates metabolic changes during skeletal muscle hypertrophy using metabolomics and finds rewiring of glycolytic intermediates into anabolic pathways, particularly the serine synthesis pathway.

An in silico cardiomyocyte reveals the impact of changes in CAMKII signalling on cardiomyocyte kinetics in hypertrophic cardiomyopathy

This study uses an in silico cardiomyocyte model to show that HCM leads to impaired crossbridge kinetics and a negative ATP supply-demand mismatch.

Non-viral induction of transient cell reprogramming in skeletal muscle to enhance tissue regeneration

This study induces transient cell reprogramming in mouse skeletal muscle using plasmid DNA to enhance tissue regeneration after injury.