Roger J. Colbran

This study investigates the role of the HEXIM1/P-TEFb complex in regulating RNA polymerase II pause release and immediate early gene induction in neurons during depolarization.

The paper shows that CaMKII clusters LTCCs via biomolecular condensation to enable excitation-transcription coupling in neurons.

The paper identifies novel endogenous CAMK2 substrates by analyzing phosphoproteomic data from double knockout mice.

This study identifies Shank3 as a key protein involved in clustering CaV1.3 L-type calcium channels under basal conditions, showing its role in complex formation and membrane localization.

This study compares behavioral phenotypes of three Camk2a mutant mouse lines with reduced CaMKII expression or activity, finding increased stereotypic jumping, hyperactivity, and reduced tactile sensitivity across all lines.

This study identifies a novel interaction between Shank3 and CaMKIIα that is essential for calcium channel signaling to the nucleus and gene expression changes during learning.