François Fuks

This study identifies mRNA glycation by methylglyoxal as a metabolic stress sensor, showing impaired translation and beta-cell dysfunction, which is mitigated by metformin.

This study identifies m3C as a novel mitochondrial mRNA modification catalyzed by METTL8, which promotes tumor progression by enhancing complex I activity and oncogenic pathways.

This study identifies Tet-dependent 5-hydroxymethylcytosine (5hmrC) modifications on mRNAs in Drosophila and shows their role in regulating axon guidance genes.

The paper investigates how RNA modifications m6A and 5hmC regulate gene expression in monocytes and macrophages during differentiation and polarization, finding their roles in transcript stability and function.

This study shows that FTO affects m6A marking on SARS-CoV-2 RNA and correlates with COVID-19 severity in patients.

This study shows that LSH regulates 5-hydroxymethylcytosine levels in mouse cells, with TET proteins relying on LSH to establish genome-wide 5hmC patterns.