Ciliogenic pancreatopathy reveals a link between ciliopathies and exocrine pancreatic disease
Memoona Rajput, Lydie C. Flasse, Esther Porée, Océane Pointeau, Alice S. Serafin, Nicolas Papadopoulos, Younès Achouri, Joel Moro, Axelle E. Loriot, Michaela Wilsch‐Bräuninger, Valentine Gillion, Nathalie Godefroid, Charlotte Bodson, Leyre López-Muneta, Constance Depestel, , Isabelle Scheers
This study identifies HNF1B and NPHP3 mutations as causes of a new pancreatic disease, ciliogenic pancreatopathy, characterized by acinar atrophy and adipose replacement, and links ciliary dysfunction to pancreatic dysfunction in humans and mice.
Gut · Aug 18, 2026Peer-reviewedCell Biology