Lisa A. Gunaydin

This study investigates neural activity in vmPFC-VMS and BLA-VMS projections during active avoidance learning and finds that vmPFC-VMS encodes both CS and avoidance, while BLA-VMS encodes avoidance, with vmPFC-VMS being necessary for active avoidance behavior.

The paper investigates neural activity in dmPFC projections during active avoidance learning in mice, finding divergent encoding in dmPFC-DMS and dmPFC-BLA projections.

The paper assesses valence processing in OCD patients and SAPAP3 knockout mice, finding similar impairments in negative and positive valence processing.

The paper shows ketamine increases fronto-striatal circuit activity, reducing compulsive grooming in a mouse model of OCD.

This study identifies fronto-striatal projections as regulators of approach-avoidance conflict, showing they control anxious avoidance behavior distinct from the dmPFC-amygdala circuit.