Alexandra Nelson

The paper shows that depolarization block in SNr neurons contributes to dystonia in a mouse model by reducing firing during dystonic attacks.

This study develops a mouse model of Parkinson's disease with impulse control disorder and shows that inhibiting indirect pathway neurons exacerbates abnormal decision-making.

This study shows that repeated levodopa treatment in Parkinsonian mice leads to striatal adaptations, specifically enhanced glutamatergic synapses on D1-MSNs and reduced D2R sensitivity, which contribute to worsening dyskinesia.

This study investigates how striatal lateral inhibition affects action selection in a mouse model of levodopa-induced dyskinesia, finding that altered inhibition contributes to involuntary movements.

This study evaluates hTau.P301S mice for PSP-like features, finding motor and eye movement impairments linked to Tau pathology.

The paper investigates how levodopa-induced dyskinesia is linked to increased activity in specific striatal direct pathway medium spiny neurons, driven by dopamine and excitatory inputs.

This study shows that chronic hyperactivation of midbrain dopamine neurons leads to their preferential degeneration, suggesting increased neural activity may contribute to Parkinson's disease pathology.

This study identifies AP-3 and VPS41 as factors that promote high-frequency dopamine release by targeting VMAT2 to axons and producing specialized synaptic vesicles.

This study uses calcium imaging and optical DBS in parkinsonian mice to show that STN DBS disrupts STN activity dynamics, not inhibition or antidromic activation, to relieve motor symptoms.

The paper shows that presynaptic NMDARs in granule cells are essential for bidirectional synaptic plasticity and motor learning in adult rodents.

This study identifies fronto-striatal projections as regulators of approach-avoidance conflict, showing they control anxious avoidance behavior distinct from the dmPFC-amygdala circuit.