Matthew Brown

Trophoblast stem cells and syncytiotrophoblasts lack inflammatory responses to LPS but retain robust interferon-mediated antiviral immunity

This study shows trophoblast stem cells and syncytiotrophoblasts do not respond to LPS but have strong interferon-mediated antiviral responses, suggesting maternal immune activation, not microbial invasion, drives early placental immunity.

Epigenetic investigation of multifocal small intestinal neuroendocrine tumours reveals accelerated ageing of tumours and epigenetic alteration of metabolic genes

This study identifies epigenetic changes and accelerated ageing in multifocal small intestinal neuroendocrine tumours, revealing altered metabolic gene regulation and tumour-specific methylation patterns.

Bayesian inference associates rare KDR variants with specific phenotypes in pulmonary arterial hypertension