Tzachi Hagai

KLHL9 acts as a KSHV vBcl-2-interacting host factor that supports lytic replication

This study identifies KLHL9 as a host factor that interacts with KSHV vBcl-2 and supports lytic replication by facilitating its mitochondrial localization and function.

Coronavirus protein interaction mapping in bat and human cells identifies molecular and genetic switches for immune evasion and replication

Decoy Antibodies Block Extracellular HSP70, Prevent Self Signaling and Inhibit Melanoma Cell Survival

This study identifies decoy antibodies targeting extracellular HSP70 on melanoma-derived melanosomes, which inhibit tumor growth and survival in preclinical models and correlate with clinical response to immunotherapy.

From bats to humans: uncovering ISG15 as a new resistance factor in type 1 diabetes

The paper identifies ISG15 as a key factor in viral resistance in pancreatic alpha cells, showing its protective role against coxsackievirus B1 in human islet cells.

Spatial and single-cell transcriptomics illuminate bat immunity and barrier tissue evolution

This study uses spatial and single-cell transcriptomics to compare bat, mouse, and human tissues, revealing immune pathway divergence and unique gene expression patterns in bat gut and lung.

Evolutionary divergence of induced versus constitutive antiviral gene expression between primates and rodents

The paper compares transcriptional divergence of antiviral genes between primates and rodents before and after viral stimulation, identifying 578 divergent orthologous genes and suggesting clade-specific adaptations.

Mapping interindividual dynamics of innate immune response at single-cell resolution

The paper develops GASPACHO to identify dynamic eQTLs in antiviral responses using single-cell RNA-seq, uncovering thousands of eQTLs and linking them to disease risk loci.

Distinct gene programs underpinning 'disease tolerance' and 'resistance' in influenza virus infection

The paper identifies two distinct gene programs associated with disease tolerance and resistance in influenza virus infection using mouse strain data.

Cardelino: Integrating whole exomes and single-cell transcriptomes to reveal phenotypic impact of somatic variants

Cardelino integrates whole exomes and single-cell transcriptomes to identify clone-of-origin and reveal phenotypic impacts of somatic variants in human fibroblasts.

Neutralizing Gatad2a-Chd4-Mbd3 Axis within the NuRD Complex Facilitates Deterministic Induction of Naive Pluripotency

This study identifies the Gatad2a-Chd4-Mbd3 subcomplex of the NuRD complex as a key inhibitor of naive pluripotency, showing that its disruption enables deterministic reprogramming of somatic cells to iPSCs.