Structure-function Analyses Reveal Key Molecular Determinants of HIV-1 CRF01_AE Resistance to the Entry Inhibitor Temsavir
Jérémie Prévost, Yaozong Chen, Fei Zhou, William David Tolbert, Romain Gasser, Halima Medjahed, Manon Nayrac, Dung Ngoc Pham Nguyen, Suneetha Gottumukkala, Ann Jones Hessell, Venigalla Basaveswara Rao, Edwin V. Pozharski, Rick K Huang, Doreen Matthies, Andrés Finzi, Marzena Pazgier
This study identifies multiple molecular determinants of HIV-1 CRF01_AE resistance to temsavir, showing that resistance involves crosstalk between His375 and inner domain layers.
Nature Communications · Oct 23, 2023Peer-reviewedMolecular Biology