Author

Romain Gasser

Centre Hospitalier de l’Université de MontréalORCID 0000-0002-8565-1106Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:protein structure prediction· 2 Assay:bulk RNA-seq· 1 Research Focus:host-pathogen & immune response· 1 Assay:protein structure· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Andrés FinziiD· 2 shared Halima Medjahed· 2 shared Jérémie PrévostiD· 2 shared Ann Jones HesselliD· 1 shared Annemarie Laumaea· 1 shared Antoine Lewin· 1 shared Cécile Tremblay· 1 shared Chantal Morrisseau· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersMolecular Biology

Andrés FinziORCID

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3 papers

Recent·Most cited

Structure-function Analyses Reveal Key Molecular Determinants of HIV-1 CRF01_AE Resistance to the Entry Inhibitor Temsavir

Jérémie Prévost, Yaozong Chen, Fei Zhou, William David Tolbert, Romain Gasser, Halima Medjahed, Manon Nayrac, Dung Ngoc Pham Nguyen, Suneetha Gottumukkala, Ann Jones Hessell, Venigalla Basaveswara Rao, Edwin V. Pozharski, Rick K Huang, Doreen Matthies, Andrés Finzi, Marzena Pazgier

This study identifies multiple molecular determinants of HIV-1 CRF01_AE resistance to temsavir, showing that resistance involves crosstalk between His375 and inner domain layers.

Nature Communications · Oct 23, 2023Peer-reviewedMolecular Biology

Decline of humoral responses against SARS-CoV-2 Spike in convalescent individuals

Guillaume Beaudoin-Bussières, Annemarie Laumaea, Sai Priya Anand, Jérémie Prévost, Romain Gasser, Guillaume Goyette, Halima Medjahed, Josée Perreault, Tony Tremblay, Antoine Lewin, Laurie Gokool, Chantal Morrisseau, Philippe Bégin, Cécile Tremblay, Valérie Martel-Laferrière, , Andrés Finzi

The paper tracks humoral responses against SARS-CoV-2 Spike in convalescent individuals over time, finding declines in IgG and IgM and neutralization capacity.

bioRxiv · Jul 9, 2020Microbiology

Genetically flexible but conserved: a new essential motif in the C-ter domain of HIV-1 group M integrases

Marine Kanja, Pierre Cappy, Nicolas Levy, Oyindamola Oladosu, Sylvie Schmidt, Paola Rossolillo, Flore Winter, Romain Gasser, Christiane Moog, Marc Ruff, Matteo Negroni, Daniela Lener

The paper identifies a conserved but genetically flexible motif in HIV-1 integrase's C-terminal domain that is essential for integration and other functions.

bioRxiv · May 26, 2020 · PreprintMolecular Biology