Treponema pallidum periplasmic and membrane proteins are recognized by circulating and skin CD4+ T cells
Tara Brinck Reid, Charmie Godornes, Victoria Louise Campbell, Kerry J. Laing, Lauren C. Tantalo, Alloysius Gomez, Thepthara Pholsena, Nicole A. P. Lieberman, Taylor M Krause, Victoria Cegielski, Lauren A. Culver, Nhi Nguyen, Denise Q. Tong, Kelly L. Hawley, Alexander L. Greninger, , David M. Koelle
The paper identifies Tp-specific CD4+ T cell responses in blood and skin of syphilis patients, showing persistence after treatment and highlighting potential vaccine targets.
The Journal of Infectious Diseases · May 10, 2024Peer-reviewedImmunology