Lauren C. Tantalo

The paper shows three T. pallidum isolates with Tp0705 PBP polymorphisms are equally susceptible to penicillin G and ceftriaxone.

This paper introduces a new MLST scheme for Treponema pallidum subspecies with high discriminatory power, validated using global clinical samples and showing distinct genetic clusters.

The paper introduces genetically encoded fluorescent tags for Treponema pallidum and Sf1Ep cells to enhance visualization and study host-pathogen interactions in syphilis research.

This study shows that long-term in vitro exposure of Treponema pallidum to sub-bactericidal doxycycline does not induce resistance, supporting the use of doxy-PEP for syphilis prevention.

The paper identifies Tp-specific CD4+ T cell responses in blood and skin of syphilis patients, showing persistence after treatment and highlighting potential vaccine targets.

The paper shows that macrolide resistance in syphilis emerged independently in multiple lineages, not just the SS14 lineage, challenging the idea that resistance drove its spread.