Kai Ma

This study identifies GLUT1 as a driver of immunotherapy resistance in ESCC by epigenetically suppressing senescence and reveals dietary glucose restriction as a potential strategy to enhance immunotherapy efficacy.

CCycDB is a functional gene database that fingerprints microbially mediated carbon cycling processes from shotgun metagenomes, outperforming existing databases in accuracy and coverage.

GeneCompass is a cross-species foundation model pre-trained on single-cell transcriptomes from human and mouse, integrating biological knowledge to improve gene regulatory mechanism understanding and downstream tasks.