Author

Sofía Nasif

University of BernORCID 0000-0001-7536-1415Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:differential expression· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Oliver MühlemanniD· 2 shared Andrea Brigitte Eberle· 1 shared Anne‐Christine UldryiD· 1 shared Daniela P. Orquera· 1 shared Flávio S. J. de SouzaiD· 1 shared Karin Schranz· 1 shared Malcolm James LowiD· 1 shared Marcelo RubinsteiniD· 1 shared

Activity by Year

2018-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersMolecular Biology

Oliver MühlemannORCID

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3 papers

Recent·Most cited

Molecular BiologyRNAPeer-reviewedOct 7, 2025

UPF1 shuttles between nucleus and cytoplasm independently of its RNA binding and ATPase activities

Sofía Nasif, Andrea Brigitte Eberle, Karin Schranz…·Oliver Mühlemann

This study shows UPF1 shuttles between nucleus and cytoplasm without needing its RNA binding or ATPase activities, with RNA binding causing cytoplasmic retention.

1 citation

humanexperimental assay

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Molecular BiologyNAR CancerPeer-reviewedJun 9, 2023

Inhibition of nonsense-mediated mRNA decay reduces the tumorigenicity of human fibrosarcoma cells

Sofía Nasif, Martino Colombo, Anne‐Christine Uldry…·Oliver Mühlemann

This study shows that inhibiting NMD reduces tumorigenicity in HT1080 fibrosarcoma cells by lowering MMP9 expression, suggesting NMD inhibition as a potential cancer therapy.

16 citations

humanbulk RNA-seq

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GeneticsbioRxivPreprintNov 4, 2018

NKX2.1 is critical for melanocortin neuron identity, hypothalamic Pomc expression and body weight

Daniela P. Orquera, María B. Tavella, Flávio S. J. de Souza…·Marcelo Rubinstein

This study shows that NKX2.1 is essential for Pomc expression in hypothalamic neurons and body weight regulation through its role in enhancer activity.

DOI 10.1101/460501

mousestatistical model

𝕏 PostBluesky