Author

Csaba Mihályi

Semmelweis UniversityORCID 0000-0001-7536-3066Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

András SzöllősiiD· 2 shared I. IordanoviD· 2 shared László CsanádyiD· 2 shared Jue CheniD· 1 shared Karol FiedorczukiD· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

5 top collaborators · 10 mutual co-author links

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2 shared papersPhysiology

András SzöllősiORCID

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2 papers

Recent·Most cited

PhysiologyProceedings of the National Academy of SciencesPeer-reviewedNov 4, 2024

Structural determinants of protein kinase A essential for CFTR channel activation

Csaba Mihályi, I. Iordanov, András Szöllősi, László Csanády

This paper identifies structural determinants of PKA-C essential for CFTR activation, showing two distinct regions mediate reversible and irreversible activation, and highlights the role of PKA-C myristoylation in this process.

7 citations

humanproteomics

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BiophysicsProceedings of the National Academy of SciencesPeer-reviewedNov 4, 2024

The structures of protein kinase A in complex with CFTR: mechanisms of phosphorylation and reversible activation

Karol Fiedorczuk, I. Iordanov, Csaba Mihályi…·Jue Chen

This study presents cryo-EM structures of PKA-C bound to CFTR, revealing mechanisms of phosphorylation and reversible activation through catalytic interactions and conformational flexibility.

27 citationstop 2%

humanprotein structure

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