Marco Mangone

This paper develops an AI-driven framework to predict and explain miRNA strand selection across species, revealing conserved rules governing this process.

The paper curates a comprehensive 3UTR dataset for C. elegans, covering 97.4% of protein-coding genes and identifies sequence elements involved in 3' end processing and miRNA targets.

This study investigates the role of ERK1/2 signaling in the development of MGE-derived glia and cortical inhibitory neurons, showing its necessity for glial number and activity-dependent responses in neurons.

This study identifies a vulva-specific transcriptome in C. elegans using immunoprecipitation of a poly(A) binding protein, revealing gene expression patterns and validating their roles in vulval development.

The paper updates a nuclear FACS sorting method to analyze the C. elegans muscle transcriptome, identifying muscle-specific genes, miRNAs, and regulatory elements.

The paper updates the C. elegans 3-UTRome resource with high-resolution 3-UTR data from 1,088 transcriptomes, enabling study of mRNA cleavage, polyadenylation, and miRNA targeting.

The paper analyzes dystrophin-deficient muscle transcriptomes in C. elegans to identify signaling pathway changes during Duchenne muscular dystrophy progression and develops a screening method for genetic partners of dystrophin.

This study identifies miRNA targets in C. elegans intestine and body muscle, revealing tissue-specific differences in miRNA regulation and its impact on RNA splicing.