Andrew L. Goodman

This study shows the type VI secretion system (T6SS) in Bacteroides acidifaciens helps maintain its presence in a wild mouse gut microbiome by antagonizing other Bacteroidales, but its effect depends on ecological context.

The paper examines how gut microbiota composition affects drug metabolism by analyzing 271 drugs across 89 microbial communities and develops models to predict microbiota-mediated drug metabolism.

The paper shows structural differences in glycan transporters drive niche partitioning in Bacteroides species by substrate chain length preference, with implications for gut microbiome ecology and dietary interventions.

The paper uses multiomics and quantitative modeling to determine how diet, host, and microbiota contribute to the host metabolome in gnotobiotic mice.