Federico E. Rey

Gut bacterial metabolite imidazole propionate potentiates Alzheimer's disease pathology

This study identifies imidazole propionate as a gut bacterial metabolite linked to Alzheimer's disease pathology through human and mouse experiments.

Gut microbes mediate the synergistic effects of dietary cholesterol and saturated fat in driving fibrosing MASH

This study shows that dietary cholesterol and saturated fat together drive fibrosing MASH via gut microbiota changes, specifically increasing Parasutterella spp. and activating hepatic stellate cells.

Investigation of Bile Salt Hydrolase Activity in Human Gut Bacteria Reveals Production of Conjugated Secondary Bile Acids

This study investigates BSH activity in human gut bacteria and finds that some strains can directly dehydrogenate conjugated bile acids to produce conjugated secondary bile acids, challenging the idea that deconjugation is a prerequisite for further modifications.

Phenotypic high-throughput screening identifies modulators of gut microbial choline metabolism

This study identifies chemical scaffolds that inhibit gut microbial choline metabolism and reduce TMAO levels in mice using phenotypic screening.

Linking interpersonal differences in gut microbiota composition and drug biotransformation activity

The paper examines how gut microbiota composition affects drug metabolism by analyzing 271 drugs across 89 microbial communities and develops models to predict microbiota-mediated drug metabolism.

Spatial characterization of microbiota profiles along the gut in a widely used mouse model: effects of high-fat diet and fructooligosaccharides

This study characterizes gut microbiota composition along the gastrointestinal tract in mice under high-fat diet and prebiotic conditions, revealing species-specific responses and challenges the translational relevance of rodent models.

Systems genetics approach uncovers associations between host amylase locus, gut microbiome and metabolic traits in hyperlipidemic mice

This study identifies genetic loci linking host amylase genes to gut microbiome composition and metabolic traits in hyperlipidemic mice.

Shaping human gut community assembly and butyrate production by controlling the arginine dihydrolase pathway

This study shows that controlling the arginine dihydrolase pathway in E. coli affects gut community assembly and butyrate production in vitro and in mice.

Trimethylamine N-oxide reduces neurite density and plaque intensity in a murine model of Alzheimer disease

This study shows that TMAO reduces neurite density and amyloid-β plaque intensity in a mouse model of Alzheimer's disease.

Polysaccharide utilization loci in Bacteroides determine population fitness and community-level interactions

The paper identifies PULs in B. uniformis that influence fitness and community interactions through glycan degradation and butyrate production.

Systems genetics uncovers microbe-lipid-host connections in the murine gut

This study identifies genetic links between gut microbiota, lipids, and host transcripts in mice, revealing key roles for Akkermansia muciniphila and ornithine lipids in microbe-host interactions.

Identification of sample mix-ups and mixtures in microbiome data in Diversity Outbred mice

The paper identifies sample mix-ups and mixtures in microbiome data from Diversity Outbred mice using shotgun sequencing reads.

Genetic determinants of gut microbiota composition and bile acid profiles in mice

This study identifies genetic loci associated with gut microbiota composition and bile acid profiles in mice using QTL analysis and validation experiments.

Autometa: Automated extraction of microbial genomes from individual shotgun metagenomes

Autometa improves microbial genome binning in metagenomes by automating clustering and taxonomic partitioning, outperforming existing methods in complex datasets.