Author

Beth A. Shen

University of WashingtonORCID 0000-0002-2327-8705Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Organism:bacteria (other)· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Assay:DNA methylation· 1 Organism:E. coli· 1

Frequent Co-Authors

Joseph D. MougousiD· 2 shared Matthew C. Radey· 2 shared Savannah K BertolliiD· 2 shared Snow Brook PetersoniD· 2 shared Andrew L. GoodmaniD· 1 shared Bentley LimiD· 1 shared Billy NgoiD· 1 shared Brandon D Duong· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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2 shared papersMicrobiology

Joseph D. MougousORCID

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3 papers

Recent·Most cited

The type VI secretion system governs strain maintenance in a wild mammalian gut microbiome

Beth A. Shen, Kyle L. Asfahl, Bentley Lim, Savannah K Bertolli, Samuel S. Minot, Matthew C. Radey, Kelsi M. Penewit, Billy Ngo, Stephen J. Salipante, Christopher D. Johnston, Snow Brook Peterson, Andrew L. Goodman, Joseph D. Mougous

This study shows the type VI secretion system (T6SS) in Bacteroides acidifaciens helps maintain its presence in a wild mouse gut microbiome by antagonizing other Bacteroidales, but its effect depends on ecological context.

eLife · Sep 15, 2026Peer-reviewedMicrobiology

A conserved electron transport chain sensitizes Bacteroides to a pore-forming type VI secretion toxin

Hannah K. Ratner, Brandon D Duong, Peng Miao, Savannah K Bertolli, Beth A. Shen, Uma Mitchell, Larry A. Gallagher, Matthew C. Radey, Snow Brook Peterson, Joseph D. Mougous

The paper identifies the Rnf electron transport chain as a susceptibility determinant for Bte2 pore-forming toxins in Bacteroides, showing its role in toxin-mediated membrane depolarization during gut colonization.

bioRxiv · Aug 29, 2025 · PreprintMicrobiology

Bacterial H-NS contacts DNA at the same irregularly spaced sites in both bridged and hemi-sequestered linear filaments

Beth A. Shen, Christine M. Hustmyer, Daniel Roston, Michael B. Wolfe, Robert C. Landick

The paper uses TEN-map to show H-NS DBDs contact DNA at the same irregularly spaced sites in both bridged and linear filaments, supporting a hemi-sequestration model.

iScience · May 18, 2022Peer-reviewedMolecular Biology