Author

Ashley W. Scadden

University of Colorado Colorado SpringsORCID 0000-0001-7603-1442Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Genetics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:fungi (other)· 2 Research Focus:benchmarking· 1 Assay:Hi-C· 1 Approach:machine learning (classical)· 1 Assay:metagenomics· 1

Frequent Co-Authors

Andrew D. KlockoiD· 2 shared Clayton Hull-CrewiD· 2 shared Abigail M. DeaveniD· 1 shared Aileen R. FerraroiD· 1 shared Alayne S. GraybilliD· 1 shared Catherine LozuponeiD· 1 shared Farh KaddariD· 1 shared Felicia Ebot-OjongiD· 1 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersGenetics

Andrew D. KlockoORCID

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3 papers

Recent·Most cited

BioinformaticsBioinformaticsPeer-reviewedDec 19, 2025

EXPLANA: A user-friendly workflow for EXPLoratory ANAlysis and feature selection in cross-sectional and longitudinal microbiome studies

Jennifer Fouquier, Maggie A. Stanislawski, John O’Connor…·Catherine Lozupone

EXPLANA is a workflow for analyzing microbiome data in cross-sectional and longitudinal studies, identifying meaningful features and generating interactive reports.

2 citations

metagenomicsmachine learning (classical)

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GeneticsProceedings of the National Academy of SciencesPeer-reviewedSep 29, 2025

Histone deacetylase-1 is required for epigenome stability in Neurospora crassa

Felicia Ebot-Ojong, Aileen R. Ferraro, Rochelle E. Yap…·Zachary Lewis

This study identifies HDA-1 as essential for maintaining epigenome stability in Neurospora crassa by regulating H3K27me3 and heterochromatin integrity.

5 citations

fungi (other)experimental assay

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GenomicsProceedings of the National Academy of SciencesPeer-reviewedNov 14, 2023

Histone deacetylation and cytosine methylation compartmentalize heterochromatic regions in the genome organization of Neurospora crassa

Ashley W. Scadden, Alayne S. Graybill, Clayton Hull-Crew…·Andrew D. Klocko

This study investigates how the HCHC complex affects genome organization in Neurospora crassa by altering histone acetylation and cytosine methylation, leading to changes in heterochromatic region compaction and interactions.

7 citations

fungi (other)Hi-C

𝕏 PostBluesky