Zachary Lewis

The paper identifies RTT109 as essential for maintaining PRC2-repressed chromatin in Neurospora crassa, showing it is required for epigenetic memory but not H3K56 acetylation.

This study shows that CAF-1 is necessary for proper structure and function of facultative heterochromatin in Neurospora crassa, working with PRC2 to silence transcription.

The paper creates a cross-species spinal cord cell type atlas integrating data from mouse, macaque, and human, identifying conserved and species-specific features.

This study identifies HELLS as a regulator of SSB repair and DNA alkylation damage response, showing its synthetic lethality with HRD in cancer.

The paper shows that PRC2 represses genes during sexual development in Neurospora crassa, and its loss leads to premature fruiting body formation.

This study identifies HDA-1 as essential for maintaining epigenome stability in Neurospora crassa by regulating H3K27me3 and heterochromatin integrity.

The paper identifies a specific subtype of dopaminergic neurons, Anxa1+, that are selectively lost in Parkinson's disease and contribute to early motor symptoms.

The paper sequences 133 Physalia genomes and analyzes citizen-science images to reveal five distinct lineages and four species, with geographic population structure and long-distance dispersal.

An automated in-situ imaging platform reads 980 RNAs and 108 proteins in FFPE tissue at subcellular resolution, with 0.0092 false calls per cell; 800,000-plus cells released publicly.

The paper introduces a cell-based assay called alk-BER to measure DNA alkylation damage and repair rates, offering a reliable and reproducible method for studying BER activity in various cell types.

The paper calculates Shannon entropy for gene expression in Neurospora crassa across 97 conditions to classify genes as constitutive or condition-specific.

The paper shows that H2A.Z is required for normal H3K27 methylation in Neurospora crassa, with EED-dependent mechanisms critical for specific genomic regions.

This paper develops DEC-AmB-LLs, Dectin-1-coated antifungal liposomes, which significantly enhance the effectiveness of amphotericin B against fungal pathogens.