Cancer BiologybioRxivPreprint
Metabolic Targeting of SREBP1 Reprograms the Obesity-Driven Ascites Immune Microenvironment and Enhances Chemotherapy Response in Obesity-Associated Ovarian Cancer
Jing Yang, Tyvette S. Hilliard, Yueying Liu…·Mary Sharon Stack
This study shows that inhibiting SREBP1 with Nelfinavir improves chemotherapy response in obesity-associated ovarian cancer by reprogramming the immune microenvironment.
DOI 10.64898/2026.09.14.751517