Matthew M. Champion

This study shows that Mycobacterium marinum switches ESX-1 substrates in response to acidic pH, affecting phagosome lysis and bacterial survival.

This study shows that tyloxapol inhibits ESX-1 secretion in Mycobacterium marinum at low concentrations, affecting its lytic activity and potentially explaining its anti-tuberculosis effects.

This study identifies N-acetyltransferases in M. marinum that link iron uptake, aminoglycoside resistance, and virulence lipid production, revealing their multifunctional roles in pathogenesis.

The paper introduces OnePotNTA, a one-pot method for quantifying N-terminal acetylation in mycobacteria, achieving high coverage and reducing sample preparation time.

This study characterizes gender- and age-related differences in the proteome of murine primary peritoneal mesothelial cells using bottom-up proteomics.

This study shows that loss of PDIM and PGL lipids in M. marinum reduces specific ESX-1 substrate secretion, impacting pathogenesis.

The paper evaluates the detection of amino acid substitutions in shotgun proteomics by creating a ground-truth library using mixed bacterial proteomes and identifies sources of bias in substitution identification.

This study identifies EspN as a critical transcription factor regulating the ESX-1 system in M. marinum, which is essential for macrophage infection and disease burden, but its activity is masked by EspM under laboratory conditions.

The paper shows that synonymous codon substitutions in E. coli can upregulate an upstream gene through cryptic transcription, challenging the view that synonymous mutations have no phenotypic effects.

The paper shows that mitochondria in Balbiani body remnants generate ATP needed for RNA transport granule formation in Xenopus oocytes.